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白細(xì)胞介素10抗體

產(chǎn)品貨號(hào)：

BN41576R
中文名稱：

白細(xì)胞介素10抗體
英文名稱：

Rabbit anti-IL-10 Polyclonal antibody
品牌：

Biorigin

貨號(hào)

產(chǎn)品規(guī)格

售價(jià)

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BN41576R-50ul

50ul

￥1486.00

交叉反應(yīng)：Mouse,Human(predicted:GuineaPig,Sheep,Rabbit,Pig,Chicken,Rat) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA
BN41576R-100ul

100ul

￥2360.00

交叉反應(yīng)：Mouse,Human(predicted:GuineaPig,Sheep,Rabbit,Pig,Chicken,Rat) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA
BN41576R-200ul

200ul

￥3490.00

交叉反應(yīng)：Mouse,Human(predicted:GuineaPig,Sheep,Rabbit,Pig,Chicken,Rat) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱	IL-10
中文名稱	白細(xì)胞介素10抗體
別名	Interleukin-10 precursor; Cytokine synthesis inhibitory factor; CSIF; Cytokine Synthesis Inhibitory Factor; IL 10; IL10A; Interleukin 10; Interleukin10; MGC126450; MGC126451; TGIF; IL10_HUMAN.

研究領(lǐng)域	細(xì)胞生物免疫學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子
抗體來(lái)源	Rabbit
克隆類型	Polyclonal
交叉反應(yīng)	Human, Mouse, (predicted: Rat, Chicken, Pig, Rabbit, Sheep, Guinea Pig, )
產(chǎn)品應(yīng)用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	18kDa
細(xì)胞定位	分泌型蛋白
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human IL-10:101-178/178
亞型	IgG
純化方法	affinity purified by Protein A
儲(chǔ) 存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	IL-10 protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Function: Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. Subunit: Homodimer. Subcellular Location: Secreted. Tissue Specificity: Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types. Similarity: Belongs to the IL-10 family. SWISS: P18893 Gene ID: 3586 Database links: Entrez Gene: 3586 Human Entrez Gene: 16153 Mouse Entrez Gene: 25325 Rat Omim: 124092 Human SwissProt: P22301 Human SwissProt: P18893 Mouse SwissProt: P29456 Rat Unigene: 193717 Human Unigene: 874 Mouse Unigene: 9868 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 白細(xì)胞介素-10(IL-10)是主要由Th2細(xì)胞所產(chǎn)生的一種細(xì)胞因子，活化的B細(xì)胞、單核巨噬細(xì)胞和枯否氏細(xì)胞（Kupffer's cell）等也可產(chǎn)生IL-10。它是以抑制Th細(xì)胞克隆細(xì)胞因子合成為特點(diǎn)的多效免疫調(diào)節(jié)因子。白介素-10是維護(hù)細(xì)胞因子網(wǎng)絡(luò)平衡的重要負(fù)調(diào)節(jié)因子。其作用機(jī)制可能是降低抗原遞呈細(xì)胞MHCⅡ類抗原表達(dá)，或誘導(dǎo)抗原遞呈細(xì)胞產(chǎn)生另一種細(xì)胞因子，改變細(xì)胞內(nèi)信號(hào)傳遞途徑，從而選擇性抑制某些細(xì)胞因子mRNA轉(zhuǎn)錄，并與Th2細(xì)胞產(chǎn)生的IL-4、IL-5有協(xié)同作用。