貨號
產(chǎn)品規(guī)格
售價
備注
BN40210R-100ul
100ul
¥2360.00
交叉反應:Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Horse) 推薦應用:WB,IHC-P,IHC-F,IF,ELISA
BN40210R-200ul
200ul
¥3490.00
交叉反應:Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Horse) 推薦應用:WB,IHC-P,IHC-F,IF,ELISA
產(chǎn)品描述
英文名稱 | GNB1 |
中文名稱 | G蛋白/鳥苷酸結(jié)合蛋白抗體 |
別 名 | G protein beta subunit GI/GS/GT; guanine nucleotide binding protein (G protein), beta polypeptide 1; guanine nucleotide-binding protein G; GBB1_HUMAN. |
研究領域 | 細胞生物 免疫學 神經(jīng)生物學 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應 | Mouse, Rat, (predicted: Human, Chicken, Dog, Pig, Cow, Horse, ) |
產(chǎn)品應用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 37kDa |
細胞定位 | 細胞漿 細胞膜 |
性 狀 | Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human G protein beta subunit GI:101-200/341 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
PubMed | PubMed |
產(chǎn)品介紹 | G protein beta subunit GI/GS/GT (guanine nucleotide-binding protein G). WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Subunit: G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2. The heterodimer formed by GNB1 and GNG2 interacts with PTH1R (via C-terminus). Post-translational modifications: Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP. Similarity: Belongs to the WD repeat G protein beta family. Contains 7 WD repeats. SWISS: P62879 Gene ID: 2782 Database links: Entrez Gene: 2782 Human Entrez Gene: 14688 Mouse Omim: 139380 Human SwissProt: P62873 Human SwissProt: P62874 Mouse Unigene: 430425 Human Unigene: 2344 Mouse Unigene: 126047 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. G蛋白又稱:鳥苷酸結(jié)合蛋白,存在于全身各個組織和細胞中,G蛋白在信息傳遞中起到很重要的作用,參與細胞內(nèi)外信息的相互傳導。 激素受體與腺苷酸環(huán)化酶是細胞膜上兩類分開的蛋白質(zhì)。激素受體結(jié)合的部分在細胞膜的外表面,而腺苷環(huán)化酶在膜的胞漿面,在兩者之間存在一種起耦聯(lián)作用的調(diào)節(jié)蛋白——鳥苷酸結(jié)合蛋白(guanine nucleotide-binding regulatory protein)細胞受到各種刺激信息,包括化學性的激素和神經(jīng)遞質(zhì)及非化學性的聲音、圖像等。刺激信息通過G蛋白的激活作用,在胞漿中生成數(shù)目眾多的第二信使分子,產(chǎn)生十萬級放大效應,引起細胞興奮,讓后促動器官完成各自功能。 1977年,美國科學家阿爾弗雷德-戈德曼-吉爾曼(Alfred Goodman Gilman)發(fā)現(xiàn)了G蛋白及其在細胞興奮傳導方面的重要作用。1994年,吉爾曼因“G蛋白”方面的研究成果而榮獲諾貝爾生理及醫(yī)學獎。 |
| 大地资源国精产品视频 | 久久久久久久久久网站 | 热久久一二三四五六馆an | 色窝窝51精品国产人妻消防 | 国产寡妇亲子伦一区二区三区 | 红桃视频在线视频一区 | 亚洲一级视频在线观看 | 国产精品伦子伦免费视频 | 黄色视频免费观看无码 | 人妻精品久久无码区新狼窝 | 高跟肉丝丝袜呻吟啪啪网站AV | 中文字幕熟女人妻丝袜丝 | 嫩草AV久久伊人妇女超级a | 国产精品久久久久久一级毛皮陈红 | 懂色AV 粉嫩AV 蜜乳AV | 免费 无码 国产在线观 | 国产清纯大学生白嫩动态图 | 免费 无码吹在线观看 | 四季AV一区二区凹凸精品 | 午夜婷婷国产麻豆精品 | 国产精品人成A片一区二区 精品 码产区一区二区三区 | 日本熟妇人熟BBW熟伦 | 精品人妇Av在线 | 白洁老师国产麻豆片 | 波多野吉衣一区二区 | 中文字幕少妇人妻 | 农村老女人A片免费播放 | 中文乱幕白丝自慰无码 | 搡老女人老太婆澡老太婆拍拍免费视频 | 人妻被黑人猛烈进入A片 | 女生粉嫩自慰网站 | 做爰高潮A片AAA视频 | 欧美毛片一区二区三区有限公司 | 国产免费一区二区三区在线播放 | 黄污视频网站在线观看污污污网 | 91丨国产丨白浆秘 喷淫 | 国产一级特黄AAA片奶水流 | 山东wBBBB搡wBBBB | 拍国产真实乱人偷精品 | 激情图片 激情小说 |