貨號
產(chǎn)品規(guī)格
售價
備注
BN40202R-100ul
100ul
¥2360.00
交叉反應(yīng):Rat,Mouse,Human(predicted:Sheep,Horse,Cow,Pig,Dog,Chicken) 推薦應(yīng)用:WB,IHC-F,IF,ELISA
BN40202R-200ul
200ul
¥3490.00
交叉反應(yīng):Rat,Mouse,Human(predicted:Sheep,Horse,Cow,Pig,Dog,Chicken) 推薦應(yīng)用:WB,IHC-F,IF,ELISA
產(chǎn)品描述
英文名稱 | GSK-3 beta |
中文名稱 | 糖原合酶激酶-3β抗體 |
別 名 | GSK 3 beta; GSK 3B; GSK-3 beta; GSK3β; Glycogen Synthase Kinase 3 Beta; Glycogen synthase kinase-3 beta; GSK 3 beta; GSK 3B; GSK3B; GSK3B protein; GSK3beta isoform; GSK3 beta; Glycogen synthase kinase-3 beta; GSK-3 beta; GSK3B_HUMAN; Serine/threonine-protein kinase GSK3B. |
研究領(lǐng)域 | 免疫學(xué) 神經(jīng)生物學(xué) 激酶和磷酸酶 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | Mouse, Rat, (predicted: Human, Chicken, Dog, Pig, Cow, Horse, Sheep, ) |
產(chǎn)品應(yīng)用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù)) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 47kDa |
細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 細(xì)胞膜 |
性 狀 | Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human GSK-3 Beta around the phosphorylation site of Ser21+Ser29:1-50/420 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲 存 液 | Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 |
保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
PubMed | PubMed |
產(chǎn)品介紹 | The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] Function: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity. Subunit: Monomer. Interacts with ARRB2 and DISC1. Interacts with CABYR, MMP2, MUC1, NIN and PRUNE Interacts with AXIN1; the interaction mediates hyperphosphorylation of CTNNB1 leading to its ubiquitination and destruction. Interacts with and phosphorylates SNAI1. Interacts with DNM1L (via a C-terminal domain). Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B. Subcellular Location: Cytoplasm. Nucleus. Cell membrane. Note=The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane. Tissue Specificity: Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney. Post-translational modifications : Phosphorylated by AKT1 and ILK1. Upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase phosphorylates and desactivates GSK3B, resulting in the dephosphorylation and activation of GYS1. Activated by phosphorylation at Tyr-216. Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. Contains 1 protein kinase domain. SWISS: P49841 Gene ID: 2932 Database links: Entrez Gene: 2932 Human Entrez Gene: 56637 Mouse Omim: 605004 Human SwissProt: P49841 Human SwissProt: Q9WV60 Mouse Unigene: 445733 Human Unigene: 394930 Mouse Unigene: 10426 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 国产精品色情无码视频A片 国产精品一区二区裸体美女 | 舔逼嫩白浆小穴图片 | 久久AV秘 一区二区三区水牛 | 天堂资源在线观看 | 午夜在线免费视频 | 熟女 - 91Porn | ThePorn.无码专区 | 免费观看www成人A片 | 国产熟女性爱乱伦网站 | 久久久无码精品秘 人口 | 红桃秘 无码一线二线三 | 又大又粗又硬又爽又黄视频 | 久久这里面都是老女人拍拍拍 | 国产黄网页视频在线播放 | 国产精品高潮呻吟久久AV无 | 河南少妇搡BBBB搡BBBB | 日本丰满少妇一区二区三区 | 国产国语对白又又粗又大又爽 | 中文字幕无码在线 | 97碰碰这里只有精彩 | 成人精品一区二区三区中文字幕 | 天美精品一区二区三区, | 亚洲精品国产成人综合久久久久久久久 | 波多野结衣在线播放 | 在线观看中文字幕2021 | 国产黄片在线免费观看 | 亚洲蜜桃精久久久久久久久久久久 | 国产裸体无遮挡免费精品视频 | 河南少妇搡BBBB搡BBBB | 肥老熟妇伦子伦456视频 | 欧美一级特黄AAAAA片大水 | 国产精品在线观看视频 | 成人性爱在线观看 | 国产免费色情网站入口大全 | 特黄AAAAAAAAA真人 | 无码国产精品一区二区三 | 无码成人精品区一级毛片 | 国产91无码精品秘入口 | 国产精品免费福利姬 | 91在线无码精品秘 入口 |